Immuno PRO Lactoferrin

An optimal formulation for enhanced protection for health

An optimal formulation for enhanced protection of skin

COMPOSITION

• Lactoferrin (milk origin) : 200mg
• Liposomal Vit D3 : 2000 IU
• Vit C : 80 mg
• Vit A : 800 mcg
• Vit E : 12 mg
• Vit B6 : 1,4 mg
• Zinc : 15 mg
• Selenium : 55 mcg

90 tablets in 1 pack → Up to 3 months treatment

Recommended dose: 1 tablet per day or according to physician’s prescription

Recommended doses:

LACTOFERRIN

• Lactoferrin is a natural iron-binding glycoprotein
• It is found in saliva, our tears, synovial fluid, white blood cells, sweat and mother’s milk 
• It has proven antifungal, antiviral, antiparasitic, anti-inflammatory, iron regulating, skin healing and immunomodulatory activities. 
• Over 8,800 clinical trials and papers written on its benefits, Lactoferrin plays a vital role within our natural immune system but also helps support skin and gut microbiome health.

How does it work? 

• Lactoferrin helps regulate how well iron is absorbed into the body from the intestine
• It binds as well Iron in the blood preventing it to be used by bacteria for their growth and virulence
• It inhibits the entry of viral particles into host cells, either by direct attachment or by blocking their cellular receptors
• It enhances natural killer cell activity and stimulates neutrophil aggregation and adhesion in immune defence
• It has an immunomodulatory effect with cytokine regulation and anti-inflammatory properties (reduces IL-6 and TNF-⍺)
• Increase the expression of Vit D receptors

LACTOFERRIN AND COVID

• There has been a renewed interest in LF for prevention and treatment adjuvant for COVID-19 in regard to its anti-binding properties.
• Many in vitro studies and some in vivo studies have been conducted with positive results
• As a well known and safe supplement, it is a good candidate as a preventive and potentially adjuvant treatment of COVID-19
• Lactoferrin and Vit D combined supplementation may represent a valid adjuvant therapeutic tool in patients with Covid-19 in light of their well-known anti-inflammatory and immunomodulatory properties.
• Prospective observational study
• 75 patients with typical symptoms of COVID-19 who tested positive on antigenic test
• Group 1: LF (128-192 mg/day) + Vit C (48-72mg) + Zn (20mg) 
• Group 2: LF (256 to 384mg/day)
• Treatment duration 10 days
• Treatment dose: 
  • 64-96 mg every 6 h daily to cure COVID-19 (256-384 mg/d). 
  • Doses can be increased to 128 mg every 6 h (512 mg) if needed. 
• Preventive dose: 
  • 64 mg two to three times daily can prevent COVID-19 (128-192 mg/d).
• Special population:
  • Pregnant women and infants under the age of two. - Mothers: 64 mg (20 ml) twice a day (128 mg/d).
  • Infants: 32 mg (10 ml) twice daily.
• Most symptoms improved significantly during first five days.
• At the moment of closing the present paper, Chang et al. empirically proposed the use of nutritional supplements of LF and commented that LF show antiviral efficacy against a wide range of virus including SARS-CoV, a closely related corona virus to SARS-COV-2 (COVID-19) and also possesses significant immunomodulatory and anti-inflammatory properties which might be of relevance to the pathogenesis of severe COVID-19 cases. Our clinical trial confirmed their assumption and elucidate the potential doses for prevention and treatment of COVID-19 infection.

VIT D PROPERTIES

• Vit D is well known for its role in calcium uptake and fixation in bones
• It is as well a key modulator of innate immunity and natural defense from acute viral respiratory infections
• COVID-19 has shown that deficiency in Vit D represent a risk factor for disease severity
• Vit D deficiency represents a global pandemic afflicting more than a billion individuals across all age group worldwide (indoor lifestyle, lack of sun in northern hemisphere, genetic predisposition)
• Deficit in Vit D is a risk factor for Severe COVID
• Role of VitD on immunity is known for years

VITAMIN C

• Vitamin C is know for year to help fight viruses infection (it is the treatment for Epstein-Barr virus infection)
• It is essential for recovery from damage caused by viral or bacterial infections, as well as for the normal functioning of the brain and many essential biochemical pathways.  
• It is the main systemic extracellular antioxidant
• Prevents toxicity from ROS and viruses. 
• When oxidized through donating an electron to reduce an ROS, it can be regenerated through a variety of mechanisms, including reducing enzymes and other antioxidants. 
• Vitamin C can support intracellular antioxidants such as GSH (glutathione) and catalase when the load of ROS is severe.
• Vitamin C also empowers the immune system, promoting chemotaxis, growth, and activity of some immune cells (macrophages, lymphocytes, natural killer cells) allowing the body to more effectively fight an infection. 
• Vitamin C has many other roles 
  • co-factor for collagen production 
  • absorption of iron, 
  • metabolism of many essential biochemicals including carnitine and neurotransmitters (e.g. norepinephrine, serotonin). 

VITAMIN E

• Supports immune system
  • Vitamin E supports the growth of T cells. 
  • Vitamin E modulates T cell function through directly impact (membrane integrity, signal transduction, and cell division)
  • Vitamin E regulates inflammatory mediators generated from other immune cells. 
• Acts as an antioxidant and prevent damages from infection
  • Vitamin E reduces cells damage

VITAMIN A

• Vitamin A is a micronutrient that is crucial for maintaining vision, promoting growth and development, and protecting epithelium and mucus integrity in the body. 
• It is known as an anti-inflammation vitamin because of its critical role in enhancing immune function. 
• It is involved in the development of the immune system and plays regulatory roles in cellular immune responses and humoral immune processes. 
• It has demonstrated a therapeutic effect in the treatment of various infectious diseases.
• Vitamin A deficiency 
  • impairs normal regeneration of mucosal barriers damaged by infection, 
  • diminishes the function of neutrophils, macrophages, and natural killer cells. 
  • diminishes antibody-mediated responses directed by Th1 and Th2 cells

ZINC

• There are a number of ways zinc supports the immune system but primarily it activates enzymes that break down proteins in viruses and bacteria so they are less able to spread.
• It also increases the activation of cells responsible for fighting infection.
• It helps cells destroy microbes such as E. coli by overloading them, this poisoning them to kill them off.
• It reduces ‘oxidative stress and damage to DNA’ that helps protect against chronic diseases.
• It reduces inflammation in the body. 
  • zinc is ‘lured’ into cells that fight infection, to help stop the immune system spiralling out of control.
  • if there wasn’t enough zinc to support this response, then excess inflammation is triggered – potentially damaging cells and the body.

SELENIUM

• Selenium is a powerful antioxidant
• Selenium interferes with oxidative stress and thereby plays an important role in the regulation of the immune system and inflammatory processes. 
• Selenium deficiency is common among most immunocompromised patients and may explain increased vulnerability of these patients to viral and bacterial infections.